Presentation and outcomes of paediatric craniopharyngioma in the west of Scotland: a 25 year experience

Xuan Ye Chanel Kuah,Angela K. Lucas-Herald, Sarah McCarrison, Roisin Boyle, Claire Adey, Anthony Amato-Watkins, Parameswaran Bhattathiri,Emer Campbell,Fiona Cowie,Liam Dorris, Ben Fulton,Diana Mcintosh,Dermot Murphy,Milind Ronghe, Roddy O’Kane, Lorraine Todd, Meharpal Sangra,Jairam Sastry, Eoghan Millar, Samih Hassan,M. Guftar Shaikh

Journal of Neuro-Oncology(2024)

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摘要
Purpose Craniopharyngiomas can be aggressive leading to significant complications and morbidity. It is not clear whether there are any predictive factors for incidence or outcomes. Our aim was therefore to record the incidence, presentation, characteristics and progression of paediatric craniopharyngiomas in the West of Scotland. Method Retrospective case note review for children diagnosed with paediatric craniopharyngiomas at the Royal Hospital for Children Glasgow, from 1995 to 2021 was conducted. All analyses were conducted using GraphPad Prism 9.4.0. Results Of 21 patients diagnosed with craniopharyngiomas, the most common presenting symptoms were headaches (17/21, 81%); visual impairment (13/21, 62%); vomiting (9/21, 43%) and growth failure (7/21, 33%). Seventeen (81%) patients underwent hydrocephalus and/or resection surgery within 3 months of diagnosis, usually within the first 2 weeks (13/21, 62%). Subtotal resection surgeries were performed in 71% of patients, and median time between subsequent resection surgeries for tumour recurrence was 4 years (0,11). BMI SDS increased at 5 year follow-up (p = 0.021) with 43% being obese (BMI > + 2SD). More patients acquired hypopituitarism post-operatively (14/16, 88%) compared to pre-operatively (4/15, 27%). A greater incidence of craniopharyngiomas were reported in more affluent areas (10/21, 48%) (SIMD score 8–10) compared to more deprived areas (6/10, 29%) (SIMD score 1–3). Five patients (24%) died with a median time between diagnosis and death of 9 years (6,13). Conclusion Over 25 years the management of craniopharyngioma has changed substantially. Co-morbidities such as obesity are difficult to manage post-operatively and mortality risk can be up to 25% according to our cohort.
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Craniopharyngioma,Outcomes,Endocrine,Risk factors
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