A microdroplet SERS-RCA biosensor with enhanced specificity and reproducibility for profiling dual miRNAs in idiopathic pulmonary fibrosis diagnosis and monitoring

Jin Qian,Linlu Zhao, Yibao Huang, Chenxiao Zhao,Heng Liu,Xiaoran Liu,Ziyi Cheng,Fabiao Yu

Chemical Engineering Journal（2024）

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摘要

•A SERS-RCA microdroplet biosensor for precise IPF diagnosis via padlock probes.•Integrated RCA chip enhances repeatability in SERS detection.•SERS-RCA offers ultra-low miRNA detection limits with broad dynamic ranges.•Dual miRNA-21 and miRNA-155 detection boosts IPF diagnosis accuracy (AUC: 0.884).•SERS-RCA sensors effectively assess IPF risk for treatment monitoring.

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关键词

surface-enhanced Raman spectroscopy,Rolling circle amplification,Idiopathic pulmonary fibrosis,Accuracy diagnosis,Microfluidic and microdroplet,miRNA

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