Convenient Total Synthesis of Bistratamides H and J

Scalable total syntheses of Bistratamides H and J with remarkable yields of 22.9 % and 24.2 % over 9 steps, respectively, have been accomplished. The key step features a PPh3-promoted cascade reaction (disulfide cleavage/thiocarbonylation/intramolecular Staudinger-aza-Wittig reaction/dehydrogenation) to construct the key Boc-L-Val-thiazole fragment, DAST-promoted oxazoline synthesis, and a PyBOP-assisted macrolactamization.