Dual-trigger release of berberine chloride from the Gelatin/Perfluorohexane core-shell structure
arxiv(2024)
摘要
The development of smart nanocarriers that enable controlled drug release in
response to internal and external triggers is an emerging approach for targeted
therapy. This study focused on designing pH-sensitive, ultrasound-responsive
gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a
model drug. The nanodroplets were prepared using an emulsion technique and
optimized by varying process parameters like homogenization rate, polymer
concentration, surfactant, drug, and perfluorocarbon content. The optimal
formulation yielded nanodroplets with a particle size of 281.7 nm, a drug
encapsulation efficiency of 66.8, and a passive drug release of 15.4 within 24
hours. Characterization confirmed successful encapsulation and pH-responsive
behavior. Ultrasound stimulation significantly enhanced drug release, with 150
kHz being more effective than 1 MHz in triggering acoustic droplet vaporization
while minimizing heat generation. After 10 minutes of radiation, the optimal
formulation showed 89.4
stability over one month at 4C. Overall, the dual-triggered nanodroplets
demonstrate excellent potential for controlled delivery and targeted release of
berberine chloride.
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