Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy

•For clinical findings, patients with LMD had an earlier stage of disease progression when receiving heart transplantation, and the degree of impairment to heart structure and function was relatively mild.•For the primate model, CRISPR-mediated adenine base editing constructed the first gene-edited primate model of DCM.•The primate model was highly similar to patients with LMD in terms of symptoms, disease progression, histopathology, and electrophysiological and transcriptional features.•Arrhythmia events in patients with LMD and the primate model predated impairment of heart structure and function.