Uncovering the Mechanism of Tenofovir Amibufenamide Fumarate Punch Sticking by Combining Direct Compression Experiment and Computational Simulation

Chenyang Zhao,Xiaolei Wang,Yanbo Liu,Xueyou Qin, Weiqi Chen, Jin Zhang,Songgu Wu,Junbo Gong

International Journal of Pharmaceutics（2024）

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摘要

•Changing the crystal morphology of API by means of crystal engineering.•Continuous pressing was used to simulate sticking in pharmaceutical manufacturing.•Sticking was explored by investigating crystal habits, excipients and structure.•Computer-aided methods explore the understanding of sticking at molecular level.

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关键词

Punch sticking,Powder compression,Morphology,Formulation,Structure characteristics

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