Advantages of Cold Atmospheric Plasma Jet Generated by Positive Pulse Voltage in Anti-Cancer Therapy

The intensity of the interaction between a helium cold atmospheric plasma jet (CAPJ) and a dielectric surface or animal skin is compared in experiment and numerical simulation. A cold plasma jet at atmospheric pressure is generated by a sinusoidal or positive pulsed voltage with different pulse durations in optimal modes. The impact effect is estimated on the basis of measured and calculated currents, line intensities in the CAPJ spectrum and temperature fields. The measured CAPJ characteristics show that the pulsed voltage for the CAPJ excitation is preferable compared to the sinusoidal mode. Varying the pulse duration of the periodic pulsed voltage makes it possible to obtain the maximum current and electric field strength at the surface within the permissible temperature in the contact area of the CAPJ with the skin of mice (<42°C). It is shown that the results of the CAPJ study obtained in physical experiments using a dielectric plate are applicable for tumor-bearing mice treatment.