Megastigmanes and Flavonoids from Seeds of Hippophae rhamnoides

Phytochemical investigation of the seeds from Hippophae rhamnoides L. led to the isolation of a new megastigmane, named (6S,9R)-9-hydroxy-4,7-megastigmadien-3-one-9-O- β -D-apiofuranosyl-(1→6)- β -D-glucopyranoside ( 1 ), together with its spatial heterogeneity which is a known megastigmane ( 2 ). Compounds 3–13 are flavonoid glycosides, 9 compounds ( 2 , 5–12 ) of which were isolated from the H. rhamnoides for the first time. Their structures were proposed through HR-ESI-MS, 1 H, and 13 C NMR data interpretation.