Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats

Hui Guan,Wenyuan Zhang,Hui Liu,Yang Jiang,Feng Li,Dan Wang,Yang Liu,Fatao He,Maoyu Wu,Geoffrey Ivan Neil Waterhouse,Dongxiao Sun-Waterhouse,Dapeng Li

Journal of Advanced Research（2024）

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摘要

•Quercetin (Q) and catechin (C) acted cooperatively against oxidative damage.•Q and C jointly ameliorated oxidative stress-induced acute alcoholic liver injury.•Q and C inhibited IKKα/p53 signaling via NF-κB-independent pathway.•FOXO3 promoted IKKα transcription by binding to the IKKα promoter region.•Q and C suppressed IKKα transcription by attaching directly to FOXO3.

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关键词

Quercetin,Catechin,Anti-oxidative stress,Transcription factor,Spectroscopy techniques

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