Clinical impact of CRS on prolonged hematotoxicity after CAR-T cell therapy: KyoTox a-score, a novel prediction model

Naokazu Nakamura,Tomoyasu Jo,Yasuyuki Arai,Toshio Kitawaki,Momoko Nishikori,Chisaki Mizumoto,Junya Kanda,Kouhei Yamashita,Miki Nagao,Akifumi Takaori-Kondo

Transplantation and Cellular Therapy（2024）

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摘要

•Post-CAR-T inflammation-related factors (CRS, peak and duration of CRP elevation, and iP-decrease) are associated with prolonged cytopenia.•A new predictive scoring system called the KyoTox a-score was developed, based upon four biomarkers that are independent of CAR-HEMATOTOX.

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关键词

chimeric antigen receptor T-cell therapy,prolonged hematotoxicity,cytokine release syndrome,inflammation

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