Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

Manon Allaire,Rola Al Sayegh,Morgane Mabire,Adel Hammoutene,Matthieu Siebert,Charles Caër,Mathilde Cadoux,JingHong Wan,Aida Habib,Maude Le Gall, Pierre de la Grange,Hervé Guillou,Catherine Postic,Valérie Paradis,Sophie Lotersztajn,Hélène Gilgenkrantz

JHEP Reports（2023）

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摘要

•Monoacylglycerol lipase (MAGL) reduces hepatocyte proliferation in human precision-cut liver slices.•Inhibiting MAGL specifically in hepatocytes delays liver regeneration by reducing liver 2-arachidonylglycerol production.•Inhibiting MAGL specifically in myeloid cells delays liver regeneration by reprogramming macrophages towards the IFN-I pathway.•Neutralising the IFN-I pathway restores liver regeneration in mice invalidated for MAGL in myeloid cells.

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关键词

Wound healing,Injury,MAGL,Proliferation

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