Pyrazole and pyrazolone derivatives as specific α-glucosidase inhibitors: in vitro combined with in silico, hemolytic and cytotoxicity studies

Ines Dhouib,Mehdi Messaad,Basma HadjKacem,Imen Fendri,Hafedh majdoub,Bassem Khemakhem

Journal of Molecular Structure（2023）

引用 1|浏览0

暂无评分

摘要

•Pyranopyrazolone (1) presents a specific inhibitory activity to the α-glucosidase.•The assessment of structure-activity relationship by docking study.•Cytotoxicity and hemolytic activities confirm the safety of the selected compound.•Potential application of compound (1) as an anti-postprandial hyperglycemia drug.

查看译文

关键词

Postprandial hyperglycemia,Metabolism,Pyrazole,Pyrazolone,In silico study,α-glucosidase

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要