MaDDOSY (Mass Determination Diffusion Ordered Spectroscopy) using an 80 MHz Bench Top NMR for the Rapid Determination of Polymer and Macromolecular Molecular Weight

Measurement of molecular weight is an integral part of macromolecular and polymer characterization which usually has limitations. Herein, this article presents the use of a bench-top 80 MHz Nuclear Magnetic Resonance (NMR) spectrometer for diffusion-ordered spectroscopy as a practical and rapid approach for the determination of molecular weight/size using a novel solvent and polymer-independent universal calibration. Using diffusion-ordered spectroscopy (DOSY) on an 80 MHz benchtop NMR system, a solvent and polymer-independent calibration is presented for the determination of the molecular weight of macromolecules without the use of deuterated solvents or cryogens. The applicability of this system in a variety of different polymers and the agreement between the DOSY measurement and conventional techniques are shown. image