Molecular testing in salivary gland cytopathology: A practical overview in conjunction with the Milan system

Recently, significant advances in the molecular characterization of salivary gland neoplasms have facilitated the classification and diagnosis of specific diagnostic entities. In the highly challenging diagnostic scenario of salivary malignancies, molecular testing is increasingly being adopted in routine practice to refine the cytological diagnosis of salivary lesions. Here, we reviewed the most recent evidence in the field of salivary glands molecular cytopathology. Significant advances have been made in the molecular characterization of salivary gland neoplasms. In this scenario, molecular testing may be adopted to refine cytological diagnosis, in particular in challenging cases. Over the past decades, molecular characterization of salivary gland neoplasms has significantly improved. In this setting, the adoption of molecular testing has become fundamental in refining challenging cytological cases.image