Assessing the risk to develop a growing teratoma syndrome based on molecular and epigenetic subtyping as well as novel secreted biomarkers

Pailin Pongratanakul,Felix Bremmer, Stella Pauls,Gereon Poschmann,Catena Kresbach,Fatma Parmaksiz,Margaretha A. Skowron, Janina Fuß,Alexa Stephan, Pia Paffenholz,Kai Stühler,Ulrich Schüller,Philipp Ströbel,Axel Heidenreich,Yue Che, Peter Albers,Daniel Nettersheim

Cancer Letters（2024）

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摘要

In germ cell tumors (GCT), a growing teratoma during chemotherapy with decreasing tumor markers was defined as ‘growing teratoma syndrome’ (GTS) by Logothetis et al. in 1982. So far, its pathogenesis and specific treatment options remain elusive.

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关键词

Germ cell tumors,Growing teratoma syndrome,Teratoma,DNA methylation,Secretome,Proteome,Biomarker

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