Nonlocal Structural Effects of Water on DNA Homology Recognition
arxiv(2024)
摘要
The mechanism behind mutual recognition of homologous DNA sequences prior to
genetic recombination is one of the remaining puzzles in molecular biology.
Leading models of homology recognition, based on classical electrostatics,
neglect the short-range nonlocal screening effects arising from structured
water around DNA, and hence may only provide insight for relatively large
separations between interacting DNAs. We elucidate the role of the effects of
the nonlocal dielectric response of water on DNA-DNA interaction and show that
these can dramatically enhance the driving force for recognition.
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