Effect of Plasma Treatment of Biomedical Scaffolds on Neuronal Cell Adhesion

The adhesive properties of scaffolds, which primarily depend on the chemical and structural features of their surface, play an important role in the tissue engineering. The cell adhesion of dissociated primary neuronal culture to isotropic and anisotropic nonwoven and sponge polylactide scaffolds was studied by fluorescence and environmental scanning electron microscopy. Neurons extracted from neonatal mouse brain showed improved adhesion on all types of scaffolds after the plasma treatment. The most pronounced effect was observed for non-oriented scaffolds.