Iodine(iii )-promoted oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois' reagent
CHEMICAL COMMUNICATIONS(2024)
摘要
A metal-free protocol for oxidative carbotrifluoromethylation of maleimides with imidazopyridines and Langlois' reagent has been developed using (diacetoxyiodo)benzene (PIDA) as an oxidant. This three-component strategy enables one-step construction of 3,4-disubstituted maleimides in good yields with high functional group tolerance. Both experimental and theoretical studies support the proposed radical reaction mechanism.
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