Novel Peroxosolvates of Quinolone Antibiotics Containing Large Hydrogen Peroxide Clusters
Mendeleev communications（2024）
Abstract
Novel class of multicomponent quinolone antibiotics,crystalline hydrogen peroxide adducts of nalidixic acid C12H12N2O3 · H2O2 and ciprofloxacin C17H18F1N3O3 · 5 H2O2, were prepared from highly concentrated hydrogen peroxide, and their structures were determined by X-ray crystallography. The second compound contains decameric H-bonded hydrogen peroxide clusters, which makes this substance one of the richest in hydrogen peroxide among organic peroxosolvates.
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Key words
peroxosolvates,hydrogen bonding,crystal packing,H-bonded clusters,multicomponent antibiotics,drug-drug cocrystals
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