Neuroprotective effects of Aucubin against cerebral ischemia–reperfusion injury

Ying Liang,Liqiu Chen, Jing Huang,Zhen Lan,Shengnan Xia, Haiyan Yang,Xinyu Bao, Xi Yu, Yingao Fan,Yun Xu,Xiaolei Zhu,Jiali Jin

International immunopharmacology（2024）

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摘要

•AU attenuates ischemic injury and inhibits the neuro-inflammatory response in MCAO mice.•AU downregulates the NF-κB and MAPK signaling pathways in ischemia–reperfusion injury.•AU alleviates post-stroke cognitive impairment and restores white matter integrity in MCAO mice.

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关键词

Aucubin,Neuroinflammation,NF‐κB pathway,MAPK pathway,Post-stroke cognitive impairment

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