Sp1-activated FGFR2 is involved in early-life exposure to nickel-induced craniosynostosis by regulating the ERK1/2 signaling pathway

Zhenkun Weng,Cheng Xu,Xiu Chen,Qing Yan,Zuqiang Fu, Jian Jiao,Jin Xu,Qian Liu,Dongmei Wang,Jingjia Liang,Wenxiang Li,Aihua Gu

Environment International（2024）

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摘要

•FGFR2-mediated ERK1/2 activation is involved in nickel-induced craniosynostosis.•Nickel upregulates FGFR2 via promoter hypomethylation and transcription factor Sp1.•Administration of AZD4547 effectively alleviates nickel-induced craniosynostosis.•FGFR2 plays mediating role in nickel-induced craniosynostosis in population study.

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关键词

Nickel,Craniosynostosis,FGFR2,ERK1/2 signaling,DNA methylation

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