Type 1 or type 2 lineage-specific promoters regulate expression of the IL-33 receptor in T cells

The alarmin IL-33 activates type 1 and type 2 immune cells via its receptor ST2 in a context-specific manner. We discovered a type 1 immunity-restricted promoter of the ST2-coding gene Il1rl1, which is located far upstream of the curated gene and is crucial for antiviral CD8+ cytotoxic T cell and CD4+ TH1 cell responses.