Transition-Metal-Free C-H Alkylation of Cyclic Aldimines with Alkylboronic Acid

Molecular oxygen-mediated C-H bond alkylation of cyclic aldimines has been reported, which avoids the use of transition metals and additional oxidants. This method allows straightforward access to a series of cyclic aldimine derivatives through a free radical course. Furthermore, this transformation features mild conditions, excellent yields and good functional group tolerance. The molecular oxygen-mediated C-H bond alkylation of cyclic aldimines with alkylboronic acids is described. This strategy allows efficiently construction of C-C bond through radical-mediated pathway, giving rise to a series of 4-alkylated cyclic aldimines with broad functional groups in the absence of transition metal catalyst and external oxidant.+image