Sulfur-Containing 1,2,3-Triazoles: Synthesis and Properties

Sulfur-containing 1,2,3-triazoles display bioactivities like antidepressant, antifungal activity, antitumor, etc. Numerous approaches have been established to form sulfur-containing 1,2,3-triazoles. 4-Sulfanyl- and 5-sulfanyl-1,2,3-triazoles were produced by metal-catalyzed azide-alkyne cycloaddition (AAC), etc. N-Sulfonyl-1,2,3-triazoles were generated via the reaction of acetylides with sulfonyl azides, CuAAC. 4-Sulfonyl-1,2,3-triazoles were produced through [3+2] cycloaddition and reaction of azide with bromovinylsulfonyl fluoride. Although 5-sulfonyl-1,2,3-triazoles were formed successfully via RuAAC, their synthetic approaches were very limited. 1-Phosphinyl-2-sulfanylethynes were suitable substances to access sulfur- and phosphorus-containing triazoles. In this review, the synthesis and properties of sulfur-containing 1,2,3-triazoles were highlighted. Initially, the properties of organosulfurs, 1,2,3-triazoles and sulfur-containing 1,2,3-triazoles were briefly introduced. After stating the general procedures to construct 1,2,3-triazole skeleton, the synthetic approaches and properties of sulfur-involved 1,2,3-triazoles were sorted and described in details. According to different kinds of sulfur-containing 1,2,3-triazoles, synthetic methods and features of 4-sulfanyl-1,2,3-triazoles, 5-sulfanyl-1,2,3-triazoles, N-sulfonyl-1,2,3-triazoles, 4-sulfonyl-1,2,3-triazoles, 5-sulfonyl-1,2,3-triazoles, sulfur- and heteroatom-containing 1,2,3-triazoles were summarized. Sulfur-containing 1,2,3-triazoles display bioactivities. Numerous approaches have been established to form sulfur-containing 1,2,3-triazoles. In this review, the synthesis and properties of sulfur-containing 1,2,3-triazoles, including 4-sulfanyl-1,2,3-triazoles, 5-sulfanyl-1,2,3-triazoles, N-sulfonyl-1,2,3-triazoles, 4-sulfonyl-1,2,3-triazoles, 5-sulfonyl-1,2,3-triazoles, sulfur- and heteroatom-containing 1,2,3-triazoles, were highlighted.image