Hybrid Cell Membrane-Coated Nanoparticles for Biomedical Applications

There is growing interest in developing cell membrane-coated nanoparticles (CNPs) for unique host cell mimicry and therapeutic applications. The continuous evolution of this technology has motivated the coating of nanoparticles with hybrid membranes originating from diverse cell types. The resulting hybrid cell membrane-coated nanoparticles (hybrid CNPs) exhibit a higher level of synergy among multifunctionalities with better multitasking capabilities than their monotypic membrane-coated counterparts. This advancement has catalyzed the initiation of numerous research opportunities, marking the advent of a promising frontier in therapeutic applications. This review outlines emerging biomedical applications of hybrid CNPs, focusing on drug targeting, immune modulation, biological neutralization, and disease diagnosis. Within each application, the review underscores how the strategic hybridization of distinct cell membranes augments the resulting nanoparticle therapeutic efficacy. Overall, the insights presented herein consolidate our understanding of current applications and may inspire novel designs with new biomedical applications. This review summarizes recent advancements in developing hybrid cell membrane-coated nanoparticles (hybrid CNPs), emphasizing their growing applications in drug targeting, immune modulation, biological neutralization, and disease diagnosis. The unique functions resulting from membrane hybridization in each hybrid CNP design are highlighted, and the future perspectives of hybrid CNPs are discussed.image (c) 2024 WILEY-VCH GmbH