Spirulina Platensis Alleviates γ- Radiation-Induced Brain Damage by Attenuating Oxidative Stress and Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels in Male Albino Rats
Indian Journal of Clinical Biochemistry(2024)
摘要
Ionizing radiation can irreversibly damage the brain cells’ function and structure. Spirulina platensis (Sp) is widely employed as a dietary supplement because it has anti-inflammatory, antioxidant, and immunomodulating properties. Therefore, this work aims to investigate the protective properties of Sp towards γ-irradiation (IRR)-induced brain damage. The whole-body male albino rats were exposed to IRR with a 7 Gy single dose in the absence or presence of Sp (400 mg/kg body weight). The rats were divided into four groups: Group I (control), Group II (Sp), Group III (IRR), and Group IV (Sp + IRR + Sp). The biochemical and histopathological investigations were evaluated two weeks post-irradiation. The results showed that irradiation increased inflammation by increasing tumor necrosis factor-alpha (TNFα), IL-1B, and IL-6 while decreasing IL-10. Additionally, irradiation evoked nucleic acid damage. Furthermore, IRR provoked oxidative stress. Similarly, the IRR caused neurotransmitter disturbances by increasing S100 calcium-binding protein (S100B) and γ- aminobutyric acid (GABA) levels while reducing brain-derived neurotrophic factor (BDNF) and glutamate levels in brain tissue. Therefore, Sp alleviated IRR-induced brain damage by attenuating the above-mentioned parameters and ameliorating histopathological changes. Consequently, it could be concluded that Sp might exert a beneficial effect on irradiation-induced brain damage by attenuating oxidative stress, regulating BDNF, and suppressing S100B.
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关键词
Spirulina Platensis,Oxidative Stress,γ-irradiation,Brain,BDNF,S100B
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