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Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study

Mennatullah M. Ibrahim,Emad B. Basalious,Mohamed A. El-Nabarawi,Amal IA. Makhlouf,Marwa Eid Sayyed,Ismail Taha Ibrahim

Drug Delivery and Translational Research（2024）

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摘要
Mirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low bioavailability, which is only 50
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关键词
Mirtazapine,Intranasal,Lipid nanocapsules,Brain,131I
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