Exosomal microRNAs in breast cancer: towards theranostic applications

Richa Gulati, Tridip Mitra, Rohan Rajiv, Emilda Judith Ezhil Rajan, Chris Pierret, Elizabeth Ann L. Enninga,Rajiv Janardhanan

FRONTIERS IN MOLECULAR BIOSCIENCES(2024)

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摘要
Breast cancer is one of the top two reproductive cancers responsible for high rates of morbidity and mortality among women globally. Despite the advancements in the treatment of breast cancer, its early diagnosis remains a challenge. Recent evidence indicates that despite the adroit use of numerous strategies to facilitate rapid and precision-oriented screening of breast cancer at the community level through the use of mammograms, Fine-needle aspiration cytology (FNAC) and biomarker tracking, no strategy has been unequivocally accepted as a gold standard for facilitating rapid screening for disease. This necessitates the need to identify novel strategies for the detection and triage of breast cancer lesions at higher rates of specificity, and sensitivity, whilst taking into account the epidemiologic and social-demographic features of the patients. Recent shreds of evidence indicate that exosomes could be a robust source of biomaterial for the rapid screening of breast cancer due to their high stability and their presence in body fluids. Increasing evidence indicates that the Exosomal microRNAs- play a significant role in modifying the tumour microenvironment of breast cancers, thereby potentially aiding in the proliferation, invasion and metastasis of breast cancer. In this review, we summarize the role of ExomiRs in the tumour microenvironment in breast cancer. These ExomiRs can also be used as candidate biomarkers for facilitating rapid screening and triaging of breast cancer patients for clinical intervention. The graphical abstract shows the ExomiRs involved in the process of proliferation, metastasis and invasion of breast cancer along with the ExomiRs involved in the drug resistance and sensitivity. This implies the diagnostic as well as therapeutic potential of these ExomiRs with respect to breast cancer, indicating that these can be used a theranostic biomarkers for early diagnosis and treatment of breast cancer.
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关键词
breast cancer,exosomal miRNAs,diagnostic markers,drug resistance,drug sensitivity
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