Evaluating the antimicrobial and electrochemical performance of phenytoin nanoparticles from Catharanthus roseus plant

Phenytoin drug was frequently prescribed to treat seizures and breast cancer, but chemically synthesized phenytoin seems to have additional adverse effects reported previously. Therefore, we have developed a phenytoin drug from Catharanthus roseus (CR) plants in nanoparticle (NPs) form for the first time using the photon-induced method (PIM). GC-MS analysis of CR-NPs revealed all the peaks indicating the presence of a phenytoin compound, and 1H NMR analysis confirmed the chemical shift of the phenytoin structure. The PXRD pattern indicates a highly crystalline nature, with a crystallite size of 25 nm. The IC50 value for the inhibition of cell growth by nano-sized particles of Catharanthus roseus (CR-NPs) is 15.91 mu g/mL, as observed in MCF-7 cell lines. Furthermore, the fabricated CR-NPs electrode exhibited a specific capacitance of 62 Fg(-1) and a current density of 1 Ag-1, with a cyclic retention of 89.27 % even after 2000 cycles. Our research offers a new perspective on the advancements of nano-sized plants, which have a significant impact on the development of natural drugs for anticancer treatment and electrochemical analysis.