Alterations in Hypothalamic-Pituitary Axis (HPA) Hormones 6 Months after Cranial Radiotherapy in Adult Patients with Primary Brain Tumors Outside the HPA Region

Cranial radiotherapy is a common treatment for brain tumors, but it can affect the hypothalamic-pituitary (H-P) axis and lead to hormonal disorders. This study aimed to compare serum levels of HPA hormones before and after cranial radiation. This study involved 27 adult patients who underwent brain tumor resection before the initiation of radiotherapy, and none had metastatic brain tumors. All participants had the HPA within the radiation field, and their tumors were located in brain areas outside from the HPA. Serum levels of HPA hormones were recorded both before and 6 months after cranial radiotherapy. A total of 27 adult patients, comprising 16 (59.3