A dozen years of ovarian tissue cryopreservation at a pediatric hospital: tracking program and patient metrics while adapting to increasing needs

Objective To review the program and patient metrics for ovarian tissue cryopreservation (OTC) within a comprehensive pediatric fertility preservation program in its first 12 years of development Design Retrospective review. Setting A tertiary children’s hospital in a large urban center between March 2011 to February 2023. Patients Pediatric patients that underwent OTC.; Interventions: Unilateral oophorectomy for OTC. Main Outcome Measures Patient demographics and clinical course information were collected for analysis. Results A total of 184 patients underwent OTC in the first 12 years. One-hundred and fifteen patients were prepubertal at the time of OTC and 69 were postpubertal. In total, 128 patients (69.6%) received part of their planned therapy prior to OTC. Starting in 2018, 104 participants (92.0%) donated tissue to research, 99 participants (87.6%) donated blood, and 102 (90.2%) donated media to research. There was a decrease in the median age of patients who underwent OTC from 16.4 to 6.6 years and an overall increase in the proportion of patients per year that were prepubertal. Forty-eight (26.0%) OTC patients were outside referrals and traveled from as far as Seattle, Washington. Conclusion During the first 12 years of this program, oncofertility research increased, annual tissue cryopreservation cases increased, and the median age of OTC patients decreased. The program adapted to build a stand-alone Gonadal Tissue Processing Suite and specialized in prepubertal ovarian tissue processing. The program will continue to adapt to patient needs in the upcoming decades as restoration technologies advance through research supported by this and collaborating programs.