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No causal association between Serum vitamin D levels and Diabetes retinopathy: A Mendelianrandomization analysis

Nutrition, Metabolism and Cardiovascular Diseases(2024)

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摘要
Background Diabetes retinopathy (DR) is a common microvascular complication of diabetes, and it is the main cause of global vision loss. The current observational research results show that the causal relationship between Vitamin D and DR is still controversial. Therefore, we conducted a Mendelian randomization study to determine the potential causal relationship between serum 25-hydroxyvitamin D (25OHD) and DR. Methods In this study, we selected aggregated data on serum 25(OH)D levels (GWAS ID: ebi-a-GCST90000615) and DR (GWAS ID: finn-b-DM_RETINOPATHY) from a large-scale GWAS database. Then use MR analysis to evaluate the possible causal relationship between them. We mainly use inverse variance weighting (IVW), supplemented by MR Egger and weighted median methods. Sensitivity analysis is also used to ensure the stability of the results, such as Cochran's Q-test, MR-PRESSO, MR-Egger interception test, and retention method. Results The MR analysis results showed that there was no significant causal relationship between 25(OH)D and DR (OR=1.0128, 95%CI=(0.9593,1.0693), P=0.6447); Similarly, there was no significant causal relationship between DR and serum 25 (OH) D levels (OR=0.9900, 95% CI=(0.9758,1.0045), P=0.1771). Conclusion Our study found no significant causal relationship between serum 25(OH)D levels and DR, and vice versa. A larger sample size randomized controlled trial is needed to further reveal its potential causal relationship.
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关键词
Mendelian randomization,Vitamin D,25(OH)D,Diabetes retinopathy
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