Water Balancing Actions of Sodium and Potassium Chlorides for Curcumin Antioxidant Activities in Oil-Water Nanoformulations

Ethanol and glycerol being 100 % water soluble hamper free radical scavenging activities (FRSA) of dispersed antioxidants, causing water scarcity as water dipoles balance the zeta-potential and stern layer kinetics. The strong electrolytes reoriented the secondary bonds of ethanol and glycerol to soften a medium resistance for philicphobic continuity attained with Mct.n state function. Herein, NaCl/KCl supplemented, sodium dodecyl sulphate (SDS), tweens (Tw-20 and Tw-40) catalysed cottonseed oil (CSO) nanoformulations in water to monodisperse curcumin (curc), are reported. The Na+, K+, Cl- nanoionic hydration spheres (NHS) have reengaged dipolar water molecules attached with ethanol and glycerol that balance a monodispersity via friccohesity (sigma) enabling (50.61-99.84)% 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) scavenging. The NHS of Na+, K+, and Cl- have homogenized curc distribution elucidated via surface tension, gamma, viscosity, eta, friccohesity, sigma, isentropic compressibility, kappa s, sound velocity, u and acoustic impedance, Z as binding forces (BF) controls. The (18.08-28.72), (32.82-37.06); (33.80-41.02), (29.36-35.88); (37.80-47.66), (30.13-41.46) gamma with SDS, Tw-20 and Tw-40, have inferred 1.15-3.45 g NaCl and 1.75-5.2 g KCl dispersion activities. Alongside, the (0.020772-0.036525) and (0.022512-0.032197) sigma, as secondary cohesive forces (CF) have revealed NHS shift in SDS-NaCl and Tw-20-KCl formulations. Ninety NaCl/KCl-SDS, Tw-20, Tw-40 permutations enabled (55.84-99.72), (50.60-99.84), (53.81-91.93)% DPPH center dot scavenging at 4.47-7.31 pH. Friccohesity resonance energy transfer (FRET) of optimized nanoformulations depicted H center dot to form H -N bond for DPPH center dot scavenging illustrated with Delta H, Delta S, E-a < 0. The NaCl/KCl could be used with other polyphenols as these have increased surface energy, enabling FRET for intimate proximities.