Deficiency in Both GLP-1R and GIPR Signaling Enhances Aeroallergen-induced Innate Airway Inflammation

Incretin mimetic drugs are currently used for treatment of type 2 diabetes. In addition, anti-inflammatory effects of the incretin signaling through glucagon-like peptide-1 receptor (GLP-1R) and gastric inhibitory peptide receptor (GIPR) have been reported. Therefore, we compared effects of signaling singly through the GLP-1R and GIPR and signaling through both receptors combined in a mouse model of airway inflammation.