Endogenous Chemerin Limits the Severity of Ozone-Induced Airway Hyperresponsiveness Irrespective of Body Mass

Tumor necrosis factor-α, a pleiotropic adipocytokine, limits the severity of airway hyperresponsiveness (AHR), a cardinal feature of asthma, in obese mice exposed to ozone (O3), a criteria pollutant and non-atopic asthma stimulus. However, in this phenomenon, the contribution of chemerin, an adipocytokine and non-chemokine chemoattractant for natural killer cells, macrophages and plasmacytoid dendritic cells, is unknown. Consequently, our goal was to asseverate the relevance of chemerin in the development of O3-induced AHR in obesity.