Ligand-Enabled Copper-Catalyzed N6-Arylation of 2′-deoxyadenosine and its analogues

A novel methodology is presented for the N6-arylation of unprotected 2′-deoxyadenosine and its analogues through the catalytic Cu(I)-mediated Ullmann reaction. This protocol demonstrates the ability to produce bioactive compounds with yields ranging from moderate to excellent. The efficacy of the reaction is attributed to the utilization of oxalic diamide as the ligand, coupled with the application of a strong base.