Direct -Arylation of Benzo[b]furans Catalyzed by a Pd₃ Cluster

As an interim paradigm for the catalysts between those based on more conventional mononuclear molecular Pd complexes and Pd-n nanoparticles widely used in organic synthesis, polynuclear palladium clusters have attracted great attention for their unique reactivity and electronic properties. However, the development of Pd cluster catalysts for organic transformations and mechanistic investigations is still largely unexploited. Herein, we disclose the use of trinuclear palladium (Pd3Cl) species as an active catalyst for the direct C-H alpha-arylation of benzo[b]furans with aryl iodides to afford 2-arylbenzofurans in good yields under mild conditions. With this method, broad substrate adaptability was observed, and several drug intermediates were synthesized in high yields. Mechanistic studies indicated that the Pd-3 core most likely remained intact throughout the reaction course.