Syntheses of Thiophenes - Recent Advances

Thiophene, as an important sulfur-containing heterocyclic, is widely used in pharmaceuticals, functional materials, and natural products. Furthermore, thiophene is of great interest to synthetic chemists due to its diverse reactivities. Over the past few decades, many synthetic strategies are developed for functionalized thiophenes. Several reviews have been reported. However, there is no review on thiophene synthesis summarized based on the sulfur sources. The current review envisioned to summary the synthesis methods for thiophene with the respect of sulfur sources and give support for choose the appropriate tools to obtain thiophene substrates. This review provides an overview of the recent synthesis methods developed and made available for thiophene products preparation. Thiophene being an important sulfur-containing heterocyclic motif finds use in pharmaceuticals, functional materials, organic chemistry and natural products, its efficient synthesis is equally important.+ image