A protein-templated selection approach for the identification of full ligands from DNA-encoded libraries
NATURE CHEMISTRY(2024)
摘要
A protein-templated selection approach has been developed for the discovery of full ligands from dual-pharmacophore DNA-encoded libraries by incorporating fragment linking into the selection process. The performance of this method was demonstrated with selections against protein-protein interaction and protein-DNA interaction targets, through which potent and selective inhibitors were identified.
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