IFN: Priming for death
JOURNAL OF CELL BIOLOGY(2024)
摘要
TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFN gamma. In this issue, Deng and colleagues dissect the mechanisms by which IFN gamma signaling combines with TNF to mediate cell death through caspase-8, discussed by James E. Vince.
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