Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFR^WT and EGFR^T790M: design, synthesis, ADMET and molecular docking

Ahmed K. B. Aljohani,Khaled El-Adl,Basmah Almohaywi,Omar M. Alatawi,Marwa Alsulaimany,Ahmed El-morsy, Sara A. Almadani,Hussam Y. Alharbi,Majed S. Aljohani,Felemban Athary Abdulhaleem M,Hanan E. M. Osman,Samy Mohamady

RSC Advances（2024）

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摘要

Fifteen new iodoquinazoline derivatives, 5a,b to 18, are reported in this study and their anticancer evaluation as dual inhibitors of EGFRWT and EGFRT790M.

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Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFRWT and EGFRT790M: design, synthesis, ADMET and molecular docking

Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFR^WT and EGFR^T790M: design, synthesis, ADMET and molecular docking