Tongue Plasmacytoma in a Dog Treated with Adjuvant Metronomic Melphalan

A 9-year-old female crossbred dog was referred due to a tongue neoformation. Marginal resection was performed to proceed with histopathological examination that indicated a malignant round cell neoplasia, and immunohistochemical staining diagnosed the mass as plasmacytoma. The owner refused another surgical intervention to extend margins and approach another mass that was verified on the ventral surface of the base of the tongue. Thus, the patient underwent three months of metronomic chemotherapy with melphalan. The disease progression was not detected at two years of follow-up.