Regenerative rehabilitation measures to restore tissue function after arsenic exposure

Environmental exposure of arsenic impairs cardiometabolic profile, skeletal muscle health, and neurological function. Such declining tissue health is observed as early as in one’s childhood where the exposure is prevalent, thereby accelerating the effect of time’s arrow. Despite the known deleterious effects of arsenic exposure, there is a paucity of specific treatment plans for restoring tissue function in exposed individuals. In this review, we propose to harness the untapped potential of existing regenerative rehabilitation programs, such as stem cell therapeutics with rehabilitation, acellular therapeutics, and artificial intelligence/robotics technologies, to address this critical gap in environmental toxicology. With regenerative rehabilitation techniques showing promise in other injury paradigms, fostering collaboration between these scientific realms offers an effective means of mitigating the detrimental effects of arsenic on tissue function.