Supplementary Figure 4 from Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer

Supplementary Figure S4 presents flow cytometric analysis of PD-1, TIGIT, and CD226 expression on GD2-2840z-CARTs and GD2-CARrejTs after coculture with SCLC-J1 cells, based on three independent experiments. It also features real-time cell analysis (RTCA) showing tumor proliferation indices over 80 hours in various conditions: alone, in coculture with GD2-CARrejTs, and control T cells, with and without anti-TIGIT and anti-PD-1 antibodies. The data illustrate the effect of these treatments on tumor growth.