One-Year Comparative Effectiveness of Upadacitinib vs Tofacitinib for Ulcerative Colitis: A Multicenter Cohort Study.
The American journal of gastroenterology(2024)
摘要
INTRODUCTION:The comparative effectiveness of upadacitinib and tofacitinib for ulcerative colitis (UC) is poorly understood.
METHODS:In this retrospective cohort study, we compared steroid-free clinical remission (SFCR) and endoscopic response/remission at 52 weeks among adults initiating upadacitinib or tofacitinib for UC.
RESULTS:A total of 155 patients initiated upadacitinib (n = 81; 30% prior tofacitinib exposure) or tofacitinib (n = 74; 0% prior upadacitinib exposure). After inverse probability of treatment-weighted logistic regression, upadacitinib was associated with significantly higher odds of SFCR (odds ratio 3.01, 95% confidence interval 1.39-6.55) vs tofacitinib. There were no differences for endoscopic response/remission.
DISCUSSION:Upadacitinib was more effective at achieving SFCR in UC at 52 weeks vs tofacitinib.
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