Shared and distinct interactions of type 1 and type 2 Epstein-Barr Nuclear Antigen 2 with the human genome

Kenyatta C. M. F. Viel,Sreeja Parameswaran,Omer A. Donmez,Carmy R. Forney,Matthew R. Hass, Cailing Yin, Sydney H. Jones, Hayley K. Prosser, Arame A. Diouf, Olivia E. Gittens, Lee E. Edsall,Xiaoting Chen, Hope Rowden,Katelyn A. Dunn,Rui Guo,Andrew VonHandorf,Merrin Man Long Leong, Kevin Ernst,Kenneth M. Kaufman, Lucinda P. Lawson, Ben Gewurz,Bo Zhao,Leah C. Kottyan,Matthew T. Weirauch

BMC Genomics（2024）

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摘要

There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins including Epstein-Barr Nuclear Antigen 2 (EBNA2). While type 1 EBNA2 is known to interact with human transcription factors (hTFs) such as RBPJ, EBF1, and SPI1 (PU.1), type 2 EBNA2 shares only 50

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关键词

Autoimmune disorders,ChIP-seq,EBNA2,EBV,Functional genomics,Gene regulation,Genetic risk loci,Transcription factors,Viruses

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