Peripheral Oedema As an Adverse Effect of Treatment of Secondary Progressive Multiple Sclerosis with Siponimod: A Case Series
Journal of neuroimmunology(2024)
摘要
Siponimod is a sphingosine 1-phosphate receptor (S1P) modulator used to treat secondary progressive multiple sclerosis (SPMS). We report 3 SPMS patients treated with siponimod who developed new or worsening peripheral oedema soon after commencing treatment. In one case, peripheral oedema resulted in immobility. Siponimod-related peripheral oedema deserves wider recognition due to the potential for morbidity and over-investigation. Clinicians should assess for pre-existing oedema and coexisting conditions that may predispose to developing peripheral oedema prior to commencing siponimod.
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关键词
Secondary progressive multiple sclerosis,Sphingosine-1 receptor modulator,Pedal,Swelling,Edema,Adverse events
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