Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics
Russian Chemical Bulletin(2024)
摘要
The synthesis of analog of Triazavirin (Riamilovir) enriched with isotopic 13C and 15N labels, viz. monohydrate of l-arginine salt of 5-methyl-6-nitro-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine was developed. To incorporate 13C and 15N stable isotopes into its structure, [5-13C]-3-amino-1,2,4-triazole (13C, 99
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关键词
[1,2,4]triazolo[1,5-a]pyrimidines,stable isotopes,spin–spin coupling constants,NMR spectroscopy
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