A Novel BODIPY-based Theranostic Agent for in Vivo Fluorescence Imaging of Cerebral Aβ and Ameliorating Aβ-associated Disorders in Alzheimer's Disease Transgenic Mice

We report the synthesis, characteristics, and biological evaluations of a novel theranostic agent, P14, for both in vitro and in vivo imaging of central Aβ plaques, inhibition of Aβ aggregation, and neuronal damage as well as behavioral deficits.