Management of invasive dental treatment for brothers with von Willebrand disease

Background von Willebrand disease (VWD) is a bleeding disorder caused by an abnormality of the von Willebrand factor protein. Case presentation Two brothers diagnosed with VWD came to our clinic, the older for caries treatment and the younger for extraction of primary teeth. To control intraoperative bleeding and postoperative hemostasis, the older brother received plasma-derived/factor VIII concentrate intravenously the day before dental treatment, while the younger brother received desmopressin preoperatively, as that was found to be effective. Conclusion For invasive dental treatment of patients with VWD, it is important to choose a plan according to patient symptoms.